Chocamine: A Clinically-Studied Cocoa Extract For Memory, Focus, and Concentration

Chocamine Cocoa Extract Logo

What Is Chocamine®?

Chocamine® is a patented cocoa-based ingredient that delivers the best of chocolate—its taste, aroma and health benefits—without the guilt, sugar, fat and dairy.

Chocamine® is the only patented cocoa-based ingredient to support
healthy cognitive function, mood and energy.

Click Here To Buy Chocamine® Cocoa Extract Powder

CoQH-CF is a unique formulation of Coenzyme Q10 (CoQ10), an important coenzyme that plays a major role in many functions throughout our body. You may already be familiar with one of our other CoQ10 softgel formulations called CoQsol-CF which we have written about in this blog. The difference between CoQsol-CF and CoQH-CF is that CoQsol-CF is made with the oxidized form of CoQ10 called ubiquinone whereas CoQH-CF is made with the reduced form of CoQ10 called ubiquinol.

There are some key differences between the two that set them apart. However, for this blog we will solely focus on what ubiquinol and more specifically, CoQH-CF does. We will have a blog discussing the key differences between ubiquinone and ubiquinol in the near future however, so keep an eye out for the comparison blog!

CoQH-CF Ubiquinol Infographic

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CoQH-CF's Unique Solubility Matrix

CoQH-CF uses a very high-quality form of Ubiquinol made by Kaneka. Kaneka produces this Ubiquinol from yeast derived Ubiquinone resulting in a bio-identical Ubiquinol supplement. In isolation, Kaneka Ubiquinol has already been shown to have good bioavailability, however, Soft Gel Technologies figured out how to further enhance this already impressive bioavailability. The technology behind the bioavailability enhancement is very well thought out and has been shown to drastically enhance Ubiquinol absorption.

The first step in enhancing Ubiquinol CoQ10 bioavailability involves controlling the crystallization of Ubiquinol CoQ10. The size of the crystals that Ubiquinol CoQ10 can form, in combination with its low water solubility, means that crystal size and shape will drastically affect bioavailability. There are multiple strategies that are used to overcome this limitation such as micronizing the powder or turning it into a paste. However, none of these methods fully eliminate the crystals in Ubiquinol CoQ10, and due to this, maximum bioavailability cannot be achieved. The best way to take crystal size and form out of the equation is to fully solvate the Ubiquinol CoQ10. This is quite hard, however, as Ubiquinol is not soluble in most common solvents such as water or glycerin. Soft Gel Technologies looked towards citrus fruits for a solution and landed on a unique citrus-based solvent called D-Limonene.

What is D-Limonene And Why Is It An CoQH-CF Ingredient?

D-Limonene is a terpene that is found in high concentrations in the peels of various citrus fruits. Lemons contain a particularly high concentration of D-Limonene and this is also where D-Limonene gets its name from. It’s safe for human consumption and even has some unique benefits of its own. D-Limonene may help promote liver health and metabolic health while also having a minor calming and stress-regulation effect. More importantly however, D-Limonene is a fantastic natural solvent that can be used to fully solvate Ubiquinol CoQ10 crystals. Furthermore, D-Limonene also has the ability to prevent Ubiquinol CoQ10 from re-crystallizing in solution.

Once the Ubiquinol CoQ10 is dissolved in the D-limonene, it is now crystal free, which is designated in the name CoQH-CF, where the CF stands for ‘Crystal Free.' The crystal free nature of the product significantly aids in absorption, in addition to consistency of absorption. Furthermore, the CoQ10 is now in solution and D-Limonene is absorbed rapidly by the body. This further increases the overall bioavailability of Ubiquinol CoQ10.

Why Is Alpha Lipoic Acid An CoQH-CF Ingredient?

The last issue that Soft Gel Technologies had to overcome, is the fact that Ubiquinol can oxidize and turn into Ubiquinone. To prevent this, Soft Gel Technologies added Alpha Lipoic Acid dissolved in capric and caprylic acid to prevent the Ubiquinol CoQ10 from oxidizing. The full solubility and antioxidant matrix that Soft Gel Technologies developed makes CoQH-CF one of the best iterations of a Kaneka Ubiquinol product available on the market. CoQH-CF is exceptionally stable and has unrivaled bioavailability. If you would like to take advantage of the plethora of Ubiquinol CoQ10 benefits, CoQH-CF should be your primary choice! Speaking of Ubiquinol benefits, what exactly are they? The rest of this article, will describe in depth, four of our favorite CoQH-CF benefits which are:

    • May help promote healthy levels of oxidation
    • May help promote cellular energy
    • May help promote healthy cardiovascular function
    • May help replenish ubiquinol stores


Cocoa Extract Powder

Did You Know?

The health benefits of chocolate come from a variety of constituents, all of which are retained in Chocamine®:


        • theobromine (standardized)
        • amino acids
        • nutritious minerals
        • biogenic amines
        • anandamides
        • polyphenols

CoQH-CF May Support Healthy Levels of Oxidation

Ubiquinol is naturally present in our bodies and one of its main purposes is to minimize the impacts of oxidative stress. Under normal conditions, this means that we are protected from a host of oxidative processes, which can have deleterious effects on our bodies and brains. As we age CoQ10 levels decline, and more specifically, our bodies have a harder time converting Ubiquinone into Ubiquinol. Since Ubiquinol is the main oxidation-regulating form of CoQ10, decreased levels of Ubiquinol could mean an increase in oxidative stress.

The increased oxidative stress that may occur after Ubiquinol levels start to decline with age may negatively impact our overall cardiovascular, metabolic and brain health. By supplementing with a high quality Ubiquinol CoQ10 supplement, such as CoQH-CF, you can help increase your bodies own antioxidant defenses. The overall net-effect this may have is a reduced rate of aging, cardiovascular health support, and cognitive function support. This means that Ubiquinol is a fantastic supplement to take as we get older.

A more in-depth analysis of the oxidation-regulating effects of Ubiquinol reveals some other interesting Ubiquinol benefits. One of the more interesting Ubiquinol benefits is that Ubiquinol may regulate the oxidation of LDL cholesterol, the “bad cholesterol”. When LDL cholesterol oxidizes, it can become very damaging to our cardiovascular system. This is one of the reasons why keeping cholesterol, and especially LDL cholesterol low, is important for optimum health. However, LDL cholesterol also has some vital functions throughout the body, such as transporting fats around the body, so we also cannot lower LDL too much. What we can do is ensure our LDL levels are in their optimal range and then supplement with Ubiquinol CoQ10 to help protect LDL cholesterol from oxidative stress.

CoQ10 may also help increase mitochondrial function, and through this mechanism, enhance energy levels through enhanced ATP production. Mitochondria are also very susceptible to oxidation as a lot of oxidative free radicals are produced within mitochondria. Ubiquinol may help prevent oxidative damage to mitochondria, thereby further enhancing mitochondrial function. By enhancing mitochondrial function, we can enhance our physical performance and enhance overall vitality!

CHOCAMINE® PROVIDES Caffeine-Free Energy

In addition to chocolate, we also have a love/hate relationship with caffeine. We love the instant energy and cognitive boost, but hate the jitters, stomachaches, sleep problems and dependency issues that come with it. The energy from theobromine differs from caffeine.

Theobromine, the energizing compound found naturally in cocoa, offers a nourishing energy boost that is more sustained than the crash-and-burn energy from caffeine. Both caffeine and theobromine are xanthine alkaloids, but the similarities end there.

      • Theobromine has a milder stimulant effect, resulting in jitter-free energy.
      • Theobromine has a longer half-life in the body, thereby providing longer-lasting. energy
      • Theobromine has been shown to have less of an effect on sleep than caffeine.
      • Theobromine is less addictive than caffeine, due to differences in adenosine receptor activity.

CoQH-CF May Promote Cellular Energy

As we briefly touched on in the section about oxidation, CoQ10 plays an important role in our mitochondria. CoQ10 can switch back and forth between Ubiquinone and Ubiquinol, and this reduction/oxidation (REDOX) reaction helps produce cellular energy in the form of ATP.

Within the Mitochondria, lies a system which produces the cellular energy our body needs. This system is called the Electron Transport Chain (ETC) and CoQ10 plays a vital role in the ETC. CoQ10 has the ability to accept electrons, and shuttle them through the ETC. In addition to this, CoQ10 helps create a proton gradient within the ETC which is ultimately what creates ATP. By supplementing with Ubiquinol CoQ10, you can both increase mitochondrial function and overall mitochondrial health.

ATP demand is much higher in highly metabolic organs such as the heart and brain and this is where CoQ10 will exert some of its most beneficial effects. By keeping the energy centers of these organs safe from oxidative damage and by enhancing their function, CoQH-CF may help enhance the health of these organs. The net effect this may have is enhanced full body health!

Chocamine Cocoa Extract Logo

Chocamine® Clinical Study Results

Results of Clinical Studies with Chocamine® for Improved Focus, Concentration and Short-Term Memory

Preliminary clinical study – 2005
Participants: 3 healthy adults
Assessment Tool: Audio-Visual Multi-processing Test (AVMT)
Dosage: 1000 mg Chocamine®
Results: The data from the AVMT studies show that consuming Chocamine® resulted in improved ability to react quickly to alternating auditory and visual commands and improved ability to ignore interfering auditory commands while remaining focused on a visual task.

Clinical study – 2009
Participants: 40 healthy volunteers
Assessment Tool: IMPACT™ Cognitive Assessment − a prominent neurocognitive research tool used by scientists in the field of neuropsychology, particularly to measure the impact of odor, flavor and the stimulation of other chemical senses.
Dosage: 1000 mg Chocamine®

      • Significant improvement in test assessing short-term memory and visual-motor response speed
      • Up to 39% improvement after Chocamine® consumption
      • Up to 49% improvement after Chocamine® Plus consumption (with added caffeine)
      • Positive trends in tests assessing reaction time and impulse control/response inhibition

CoQH-CF May Promote Cardiovascular Health

As we have already discussed, CoQ10 is an essential component of overall health as it is used to produce the energy that is vital for organ function. The heart, in particular, has a very high concentration of mitochondria and CoQ10. So it is important for overall cardiovascular health that adequate levels of CoQ10 are maintained. By supplementing with CoQ10, we may be able to help our heart perform at optimal levels by providing it with the energy that it needs. In fact, research has shown that CoQ10 is a highly beneficial supplement for maintaining overall cardiovascular health. As we discussed earlier, Ubiquinol CoQ10 may also help protect us from oxidized LDL which does not support cardiovascular health.

Furthermore, Ubiquinol CoQ10 may also help enhance blood flow. This effect may be attributed to it oxidation-regulating effects which can help preserve levels of nitric oxide in our blood vessels. Nitric oxide has the ability to relax the walls of our blood vessels, a process known as vasodilation. By increasing vasodilation, CoQH-CF may be able to optimize blood flow which may help enhance overall cardiovascular function even further.

Overall, CoQH-CF would be a fantastic product to take if you want to help optimize your cardiovascular function. This can be beneficial for a wide range of individuals such as athletes or just those seeking a little bit more vitality.


Chocamine® — More Than Just Energy!

The following benefits are supported by general research and conventional wisdom:

        • Energy, endurance & stamina
        • Mental acuity & concentration
        • Mood & outlook
        • Cravings & satisfaction
        • Healthy circulation

CoQH-CF May Help Replenish Ubiquinol Stores

One of the hallmarks of aging is a loss of total CoQ10, and more specifically, a loss of Ubiquinol. Research has shown that individuals over the age of 40 may already start experiencing decreased stores of CoQ10 and Ubiquinol. As has become clear throughout this article, maintaining adequate CoQ10 levels is very important to supporting optimal health. With this in mind, we would particularly suggest CoQH-CF supplementation to people over the age of 40. That being said, anyone who is 18 or older can benefit greatly from enhancing their CoQ10 stores, and more specifically, their Ubiquinol stores.

If you are above the age of 40, replenished Ubiquinol stores may give you a restored sense of vitality. You will have more daytime energy and have an easier time getting in some solid physical exercise. Furthermore, enhanced Ubiquinol stores may also help enhance cognitive function which is always a fantastic added bonus!

For those under the age of 40, replenishing Ubiquinol stores can still have benefits. For example, it has been shown that CoQ10 may help with headaches, muscle function and mood. This makes CoQH-CF a very versatile supplement and no matter what your age, you can benefit from adding a CoQH-CF supplement to your daily supplement regime!

How To Take A CoQH-CF Supplement

Since CoQH-CF is a solubilized form of Ubiquinol, it matters much less whether you take it with our without food. This makes dosing easy and consistent as the CoQH-CF will absorb reliably and consistently. In addition to its highly enhanced bioavailability, the enhanced ease of dosing makes this one the the best ubiquinol supplement currently out on the market.

CoQH-CF Recommended Dosage

The recommended Ubiquinol dose, as is contained in CoQH-CF is set at 100 mg per dose. This will provide you with a large Ubiquinol dose, allowing you to experience all of the Ubiquinol benefits to their fullest potential!

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Nootropics Depot is an online-based vendor of high quality nootropics, novel plant extracts, amino acids, fish oil, choline supplements, vitamins, and more based in Tempe Arizona. We were founded in 2013 when we realized the industry needed a trusted source for these products and someone to champion the change the supplement industry needs. We have our own in-house analytical testing lab with some of the best analytical chemists in the supplement industry. We are constantly striving to advance and improve the purity and analytical standards of not only the nootropics industry, but the larger supplement industry as a whole.

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Chocamine: A Clinically-Studied Cocoa Extract For Memory, Focus, and Concentration