Myelin loss may explain how autism-linked DNA deletion affects cognition
Mice that lack one copy of TBX1, a gene in the autism-linked 22q11.2 chromosomal region, produce too little myelin — the fatty insulation that
Tag : 22q11
2 min read
Copy number variations linked to autism have diverse but overlapping effects
People with mutations in distant chromosomal regions often share a range of autism traits, even if they do not meet the diagnostic threshold for
5 min read
How polygenic scores can improve predictions about autism, schizophrenia
Advances in genetic research have revealed that some mutations can lead to a wide array of outcomes. About 21 percent of people with deletions in the
5 min read
Hot topics in autism research, 2020
Despite a global pandemic and lockdowns that temporarily stymied research, autism scientists made significant progress in many areas in 2020 — from
3 min read
Drug helps mice with autism-linked mutation recognize others
A drug that has been tested in clinical trials as a treatment for depression restores social memory in a mouse model of 22q11.2 deletion syndrome,
3 min read
Gene expression maps reveal origins of brain changes from autism mutations
A new study pinpoints genes and cell types that may account for the atypical brain structure in people with genetic conditions related to
3 min read
Gene mutations point to overlaps in brain connectivity for autism, schizophrenia
People who have large mutations associated with autism and schizophrenia share atypical patterns of brain connectivity, according to a new study,
3 min read
Brain organoids reveal neuronal flaws in syndrome tied to autism
Neurons derived from people with 22q11.2 deletion syndrome, a genetic condition linked to autism, show deficits in electrical activity and calcium
3 min read
Autistic people with rare mutation may have unique brain anatomy
Autistic people with deletions in the chromosomal region 22q11.2 have a brain structure that’s distinct from that of autistic people without the
3 min read
Fine-tuning brain activity reverses memory problems in mice with autism mutation
Dampening overactive brain circuits alleviates social and spatial memory problems in a mouse model of 22q11.2 deletion syndrome, according to a new
4 min read
New Understanding of Schizophrenia
Node Smith, ND Schizophrenia causes hallucinations and memory or cognition problems inter alia. This psychiatric illness affects 0.5% of the general