Moving Polygenic Risk Scores into the Clinic
Genetic testing is widely used to diagnose monogenic diseases that are caused by mutations in a single gene, such as cystic fibrosis or sickle cell
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Moving Polygenic Risk Scores into the Clinic
Genetic testing is widely used to diagnose monogenic diseases that are caused by mutations in a single gene, such as cystic fibrosis or sickle cell
Sepsis-Associated Variants Integrated into Polygenic Risk Score
Written by Vered Smith, Science Writer Researchers at the University of Michigan have published a study in PLOS ONE identifying genetic variants
Go big or stay home! Small neuroimaging association studies just generate noise.
Figuring out the neural basis of differences between individuals or groups in all kinds of psychological traits or psychiatric conditions is a major
What have we learned from psychiatric genetics? The view from 2022.
It has been recognised for millennia that risk of mental illness (broadly defined) tends to run in families. Modern science has confirmed that
Genetic atlases reveal new landscapes in brain structure
An international team has used genetic atlases of the human brain to identify hundreds of new genomic loci that help explain brain
GWAS identifies new acne risk genes
A genome-wide association study (GWAS) of acne has identified 29 regions of the genome that influence the condition. Acne vulgaris Acne vulgaris is a
Largest genetic study of migraine reveals new genetic risk factors
An international consortium of leading migraine scientists has identified over 120 regions of the genome that are connected to risk of
Mitochondrial DNA levels may underlie human diseases
A new study, published in eLife, has identified mitochondrial DNA levels as a potential biomarker of diseases such as cancer and dementia. The
9 min read
The Bird paper, and hereditarian predictions
Kevin Bird (2016) I keep getting asked about this, so I figure a short note is in order. Some months ago, Commie Kevin (Twitter) AKA. Kevin Bird
New gene discoveries in the development of stuttering
Ground-breaking research, led by scientists at Vanderbilt University Medical Center, has reported the discovery of new genetic variants associated
New research finds ABI3 gene function in Alzheimer’s disease
Scientists have found that loss of ABI3 function, a protein-coding gene, may increase the risk of developing Alzheimer’s disease by affecting
1 min read
State of genetic predictions: an example
While we don’t take anecdotes too seriously on this blog, here I will present a small one. If you are one of those who have purchased genetic test
Ashkenazi Jews are extremely inbred
Neurologists are inherently interested in psychosis, not least because too much dopamine in the form of L-DOPA can trigger it. I’ve
15 min read
The amoral nonsense of Orchid’s embryo selection
If you haven’t heard about Clubhouse yet… well, it’s the latest Silicon Valley unicorn, and the popular new chat hole for thought leaders. I